Garvican L1,2, Martin D, 1 Quod M1, Stephens B1, Sassi A3, Gore C1
1, Department of Physiology, Australian Institute of Sport, Canberra, Australia;2, Exercise Physiology Laboratory, Flinders University,Bedford Park, South Australia, Australia; 3, Human Performance Lab, Mapei Sport Research Center, Castellanza, Italy
To determine the time course of hemoglobin mass Hbmass to natural altitude training, Hbmass, erythropoietin [EPO], reticulocytes, ferritin and soluble transferrin receptor (sTfR) were measured in 13 elite cyclists during, and 10 days after, 3 weeks of sea level (n=5) or altitude (n=8, 2760 m) training. Mean Hbmass, with a typical error of ∼2%, increased during the first 11 days at altitude (mean ± standard deviation 2.9 ± 2.0%) and was 3.5 ± 2.5% higher than baseline after 19 days. [EPO] increased 64.2 ± 18.8% after 2 nights at altitude but was not different from baseline after 12 nights. Hbmass and [EPO] did not increase in sea level. Reticulocytes (%) were slightly elevated in altitude at Days 5 and 12 (18.9 ± 17.7% and 20.4 ± 25.3%), sTfR was elevated at Day 12 (18.9 ± 15.0%), but both returned to baseline by Day 20. Hbmass and [EPO] decreased on descent to sea level while ferritin increased. The mean increase in Hbmass observed after 11 days (∼300 h) of altitude training was beyond the measurement error and consistent with the mean increase after 300 h of simulated live high: train low altitude. Our results suggest that in elite cyclists, Hbmass increases progressively with 3 weeks of natural altitude exposure, with greater increases expected as exposure persists.
Scand J Med Sci Sports. 2012 Feb;22(1):95-103.